Set packing takes a universe U and a family F of subsets of U, and asks for the largest subfamily of pairwise-disjoint sets:
Karp reduced clique to (1) — and in fact the two are interreducible. Disjointness in the set system corresponds to non-adjacency, then to adjacency in the complement graph, and a packing is a clique.
The optimization version is hard to approximate within a factor of
making this one of the genuinely brutal members of the 21: the gap (2) means even getting close to optimal is essentially as hard as solving exactly.