Each requirement defines a set of tests that exercise it. A regression suite that hits every requirement is a hitting set on this family. CI pipelines at Google, Facebook, and Microsoft run test minimization daily to keep cycle times under control — the optimal selection is a hitting set, the deployed heuristic is greedy. The same problem runs in threat indicator matching in SIEM systems (each malware family defined by a set of indicators of compromise; pick the smallest sensor set that catches every family), in clinical diagnostic panels (cover every condition in a differential with the fewest tests), and in fault localization (pick the smallest set of program edits that explains every failing test).
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Test suite minimization
Given thousands of regression tests covering hundreds of requirements, the smallest test suite that covers every requirement is a hitting set.